Drug interactions
Nevirapine + Tenofovir df
Severity: Minor
Nevirapine and Tenofovir df: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are components of standard antiretroviral regimens and there is no pharmacokinetic interaction of concern. Immune reconstitution inflammatory syndrome can occur with any effective antiretroviral therapy rather than from this combination specifically.
What this interaction means in plain words
Nevirapine and Tenofovir df have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No direct interaction; immune reconstitution follows recovery of immune function on antiretroviral therapy generally.
What to do
No dose adjustment is needed. Monitor for inflammatory symptoms of opportunistic infections after starting therapy in patients with low CD4 counts.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Nevirapine with Tenofovir df?
MediHelp rates the interaction as minor. Nevirapine and Tenofovir df have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both are components of standard antiretroviral regimens and there is no pharmacokinetic interaction of concern. Immune reconstitution inflammatory syndrome can occur with any effective antiretroviral therapy rather than from this combination specifically.
How serious is the interaction between Nevirapine and Tenofovir df?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for inflammatory symptoms of opportunistic infections after starting therapy in patients with low CD4 counts.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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