Drug interactions
Nevirapine + Tezacaftor
Severity: Major
Nevirapine and Tezacaftor: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine induces CYP3A4 and can lower tezacaftor plasma concentrations. Reduced exposure may weaken the CFTR-modulating effect and lead to loss of respiratory benefit.
What this interaction means in plain words
Nevirapine and Tezacaftor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Nevirapine induces CYP3A4, increasing the metabolism of tezacaftor, which is a CYP3A substrate.
What to do
Avoid combining with nevirapine where possible, since labeling advises against strong CYP3A inducers with tezacaftor/ivacaftor; consider an alternative antiretroviral such as an integrase inhibitor. If unavoidable, monitor lung function and clinical response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Nevirapine with Tezacaftor?
MediHelp rates the interaction as major. Nevirapine and Tezacaftor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nevirapine induces CYP3A4 and can lower tezacaftor plasma concentrations. Reduced exposure may weaken the CFTR-modulating effect and lead to loss of respiratory benefit.
How serious is the interaction between Nevirapine and Tezacaftor?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining with nevirapine where possible, since labeling advises against strong CYP3A inducers with tezacaftor/ivacaftor; consider an alternative antiretroviral such as an integrase inhibitor. If unavoidable, monitor lung function and clinical response.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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