Drug interactions
Nevirapine + Triazolam
Severity: Moderate
Nevirapine and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may reduce triazolam concentrations, leading to reduced sedative and hypnotic effect. Patients may report poorer sleep control.
What this interaction means in plain words
Nevirapine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nevirapine induces CYP3A4, the main enzyme metabolizing triazolam.
What to do
Monitor for diminished hypnotic effect and adjust the dose cautiously or choose an alternative agent not dependent on CYP3A4.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Nevirapine with Triazolam?
MediHelp rates the interaction as moderate. Nevirapine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine may reduce triazolam concentrations, leading to reduced sedative and hypnotic effect. Patients may report poorer sleep control.
How serious is the interaction between Nevirapine and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for diminished hypnotic effect and adjust the dose cautiously or choose an alternative agent not dependent on CYP3A4.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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