Drug interactions
Nevirapine + Ulipristal
Severity: Major
Nevirapine and Ulipristal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine can lower ulipristal concentrations, which may reduce the efficacy of emergency contraception. Unintended pregnancy is the main clinical concern.
What this interaction means in plain words
Nevirapine and Ulipristal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Nevirapine induces CYP3A4, increasing the metabolism of ulipristal.
What to do
Avoid ulipristal in patients taking nevirapine and use a copper intrauterine device as emergency contraception. Levonorgestrel may be considered only with awareness of reduced efficacy and specialist advice.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Nevirapine with Ulipristal?
MediHelp rates the interaction as major. Nevirapine and Ulipristal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nevirapine can lower ulipristal concentrations, which may reduce the efficacy of emergency contraception. Unintended pregnancy is the main clinical concern.
How serious is the interaction between Nevirapine and Ulipristal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ulipristal in patients taking nevirapine and use a copper intrauterine device as emergency contraception. Levonorgestrel may be considered only with awareness of reduced efficacy and specialist advice.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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