Drug interactions
Nevirapine + Vorapaxar
Severity: Moderate
Nevirapine and Vorapaxar: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may reduce vorapaxar exposure, potentially weakening its antiplatelet effect. This may raise the risk of atherothrombotic events.
What this interaction means in plain words
Nevirapine and Vorapaxar can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nevirapine induces CYP3A4, which is the main pathway for vorapaxar elimination.
What to do
Avoid the combination where feasible, or choose an alternative antiretroviral or antiplatelet strategy. Monitor for cardiovascular events if used together.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Nevirapine with Vorapaxar?
MediHelp rates the interaction as moderate. Nevirapine and Vorapaxar can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine may reduce vorapaxar exposure, potentially weakening its antiplatelet effect. This may raise the risk of atherothrombotic events.
How serious is the interaction between Nevirapine and Vorapaxar?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where feasible, or choose an alternative antiretroviral or antiplatelet strategy. Monitor for cardiovascular events if used together.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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