Drug interactions
Nevirapine + Zaleplon
Severity: Minor
Nevirapine and Zaleplon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zaleplon is mainly metabolized by aldehyde oxidase with a minor CYP3A4 contribution, so nevirapine may modestly reduce exposure. A meaningful loss of hypnotic effect is unlikely.
What this interaction means in plain words
Nevirapine and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nevirapine belongs to Anti Virals; Zaleplon belongs to Central Nervous System.
Why it happens
Weak CYP3A4 induction by nevirapine slightly increases zaleplon metabolism.
What to do
No empiric adjustment is needed; reassess sleep response if efficacy appears reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Zaleplon
- Calcium / magnesium / potassium / sodium oxybates + Zaleplon Contraindicated
- Sodium oxybate + Zaleplon Contraindicated
- Brexanolone + Zaleplon Major
- Buprenorphine long-acting + Zaleplon Major
- Buprenorphine subdermal implant + Zaleplon Major
- Buprenorphine transdermal + Zaleplon Major
Frequently asked questions
Can I take Nevirapine with Zaleplon?
MediHelp rates the interaction as minor. Nevirapine and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zaleplon is mainly metabolized by aldehyde oxidase with a minor CYP3A4 contribution, so nevirapine may modestly reduce exposure. A meaningful loss of hypnotic effect is unlikely.
How serious is the interaction between Nevirapine and Zaleplon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric adjustment is needed; reassess sleep response if efficacy appears reduced.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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