Drug interactions
Nevirapine + Zolpidem
Severity: Minor
Nevirapine and Zolpidem: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zolpidem is metabolized mainly by CYP3A4, so nevirapine may reduce its levels and hypnotic effect. Strong inducers such as rifampin have shown this, but nevirapine data are limited.
What this interaction means in plain words
Nevirapine and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nevirapine belongs to Anti Virals; Zolpidem belongs to Central Nervous System.
Why it happens
CYP3A4 induction by nevirapine increases zolpidem clearance.
What to do
Reassess sleep response and adjust zolpidem dose within labeled limits if efficacy is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Zolpidem
Frequently asked questions
Can I take Nevirapine with Zolpidem?
MediHelp rates the interaction as minor. Nevirapine and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zolpidem is metabolized mainly by CYP3A4, so nevirapine may reduce its levels and hypnotic effect. Strong inducers such as rifampin have shown this, but nevirapine data are limited.
How serious is the interaction between Nevirapine and Zolpidem?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reassess sleep response and adjust zolpidem dose within labeled limits if efficacy is inadequate.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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