Drug interactions
Nicardipine + Paclitaxel
Severity: Minor
Nicardipine and Paclitaxel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine inhibits P-glycoprotein in vitro and could raise paclitaxel exposure. The clinical effect is not well established, but paclitaxel has a narrow therapeutic index.
What this interaction means in plain words
Nicardipine and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nicardipine belongs to Cardiovascular; Paclitaxel belongs to Oncology.
Why it happens
Possible inhibition of P-glycoprotein efflux of paclitaxel by nicardipine; clinical significance is unproven.
What to do
No routine adjustment is needed. Watch for increased paclitaxel toxicity such as neutropenia and neuropathy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Paclitaxel
Frequently asked questions
Can I take Nicardipine with Paclitaxel?
MediHelp rates the interaction as minor. Nicardipine and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine inhibits P-glycoprotein in vitro and could raise paclitaxel exposure. The clinical effect is not well established, but paclitaxel has a narrow therapeutic index.
How serious is the interaction between Nicardipine and Paclitaxel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Watch for increased paclitaxel toxicity such as neutropenia and neuropathy.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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