Drug interactions
Nicardipine + Phentolamine
Severity: Moderate
Nicardipine and Phentolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure through vasodilation. Together they can cause excessive hypotension and reflex tachycardia.
What this interaction means in plain words
Nicardipine and Phentolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Phentolamine belongs to Cardiovascular.
Why it happens
Additive vasodilation: calcium channel blockade plus alpha-adrenergic blockade.
What to do
Monitor blood pressure and heart rate closely and titrate each drug to effect. Reduce the dose if hypotension or marked tachycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Phentolamine
Frequently asked questions
Can I take Nicardipine with Phentolamine?
MediHelp rates the interaction as moderate. Nicardipine and Phentolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure through vasodilation. Together they can cause excessive hypotension and reflex tachycardia.
How serious is the interaction between Nicardipine and Phentolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate closely and titrate each drug to effect. Reduce the dose if hypotension or marked tachycardia develops.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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