Drug interactions
Nicardipine + Regorafenib
Severity: Moderate
Nicardipine and Regorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine may inhibit CYP3A4 and modestly alter regorafenib and its active metabolite exposure. The clinical effect on efficacy and toxicity is uncertain.
What this interaction means in plain words
Nicardipine and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Regorafenib belongs to Oncology.
Why it happens
Possible CYP3A4 inhibition altering regorafenib metabolism; nicardipine is only a weak to moderate inhibitor.
What to do
Monitor for regorafenib toxicity such as hand-foot reaction, hypertension and liver enzyme elevation. Consider an alternative antihypertensive if concerns arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Regorafenib
Frequently asked questions
Can I take Nicardipine with Regorafenib?
MediHelp rates the interaction as moderate. Nicardipine and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine may inhibit CYP3A4 and modestly alter regorafenib and its active metabolite exposure. The clinical effect on efficacy and toxicity is uncertain.
How serious is the interaction between Nicardipine and Regorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for regorafenib toxicity such as hand-foot reaction, hypertension and liver enzyme elevation. Consider an alternative antihypertensive if concerns arise.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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