Drug interactions
Nicardipine + Riociguat
Severity: Moderate
Nicardipine and Riociguat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, so combined use may cause symptomatic hypotension. Nicardipine may also inhibit BCRP, possibly raising riociguat exposure, though this is not well characterized.
What this interaction means in plain words
Nicardipine and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Riociguat belongs to Cardiovascular.
Why it happens
Additive vasodilatory effects, with possible BCRP inhibition by nicardipine increasing riociguat levels.
What to do
Monitor blood pressure and symptoms of hypotension when starting or adjusting either drug. Reduce the riociguat or nicardipine dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Riociguat
- Avanafil + Riociguat Contraindicated
- Dipyridamole + Riociguat Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Riociguat + Sildenafil Contraindicated
Frequently asked questions
Can I take Nicardipine with Riociguat?
MediHelp rates the interaction as moderate. Nicardipine and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure, so combined use may cause symptomatic hypotension. Nicardipine may also inhibit BCRP, possibly raising riociguat exposure, though this is not well characterized.
How serious is the interaction between Nicardipine and Riociguat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of hypotension when starting or adjusting either drug. Reduce the riociguat or nicardipine dose if hypotension occurs.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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