Drug interactions
Nicardipine + Saxagliptin-metformin
Severity: Minor
Nicardipine and Saxagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine is a weak to moderate CYP3A4 inhibitor, not a strong one, so any rise in saxagliptin exposure is small and does not require the strong-inhibitor dose cap. Calcium channel blockers may also modestly impair glucose tolerance, with little effect in most patients.
What this interaction means in plain words
Nicardipine and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nicardipine belongs to Cardiovascular; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Weak CYP3A4 inhibition may slightly raise saxagliptin levels, and calcium channel blockade may marginally reduce insulin secretion.
What to do
No dose change is usually needed; monitor glucose control periodically.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin-metformin
Other interactions of Nicardipine
Frequently asked questions
Can I take Nicardipine with Saxagliptin-metformin?
MediHelp rates the interaction as minor. Nicardipine and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine is a weak to moderate CYP3A4 inhibitor, not a strong one, so any rise in saxagliptin exposure is small and does not require the strong-inhibitor dose cap. Calcium channel blockers may also modestly impair glucose tolerance, with little effect in most patients.
How serious is the interaction between Nicardipine and Saxagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor glucose control periodically.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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