Drug interactions
Nicardipine + Tamsulosin
Severity: Moderate
Nicardipine and Tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine weakly to moderately inhibits CYP3A4 and is itself a vasodilator. Together they may add to blood pressure lowering and orthostatic dizziness.
What this interaction means in plain words
Nicardipine and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Tamsulosin belongs to Genitourinary.
Why it happens
Combined alpha-blockade and calcium channel blocker vasodilation, plus possible CYP3A4 inhibition raising tamsulosin levels.
What to do
Monitor blood pressure and orthostatic symptoms, particularly at initiation or dose changes. Advise the patient to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Nicardipine
Frequently asked questions
Can I take Nicardipine with Tamsulosin?
MediHelp rates the interaction as moderate. Nicardipine and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine weakly to moderately inhibits CYP3A4 and is itself a vasodilator. Together they may add to blood pressure lowering and orthostatic dizziness.
How serious is the interaction between Nicardipine and Tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, particularly at initiation or dose changes. Advise the patient to rise slowly.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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