Drug interactions
Nicardipine + Ticagrelor
Severity: Minor
Nicardipine and Ticagrelor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine is a weak to moderate CYP3A4 inhibitor and may slightly increase ticagrelor exposure. This is unlikely to be clinically important in most patients, though bleeding risk could rise.
What this interaction means in plain words
Nicardipine and Ticagrelor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nicardipine belongs to Cardiovascular; Ticagrelor belongs to Cardiovascular.
Why it happens
Mild inhibition of CYP3A4-mediated ticagrelor metabolism by nicardipine.
What to do
No dose adjustment is required. Monitor for bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Frequently asked questions
Can I take Nicardipine with Ticagrelor?
MediHelp rates the interaction as minor. Nicardipine and Ticagrelor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine is a weak to moderate CYP3A4 inhibitor and may slightly increase ticagrelor exposure. This is unlikely to be clinically important in most patients, though bleeding risk could rise.
How serious is the interaction between Nicardipine and Ticagrelor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. Monitor for bleeding.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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