Drug interactions
Nicardipine + Tinidazole
Severity: Minor
Nicardipine and Tinidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine is a CYP3A4 inhibitor in vitro and may modestly raise tinidazole exposure. Clinical relevance is likely limited given tinidazole's wide margin and short courses.
What this interaction means in plain words
Nicardipine and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nicardipine belongs to Cardiovascular; Tinidazole belongs to Anti Parasitic.
Why it happens
Nicardipine inhibits CYP3A4, which may reduce tinidazole metabolism.
What to do
No dose change is generally needed; monitor for tinidazole adverse effects such as nausea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Other interactions of Nicardipine
Frequently asked questions
Can I take Nicardipine with Tinidazole?
MediHelp rates the interaction as minor. Nicardipine and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine is a CYP3A4 inhibitor in vitro and may modestly raise tinidazole exposure. Clinical relevance is likely limited given tinidazole's wide margin and short courses.
How serious is the interaction between Nicardipine and Tinidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor for tinidazole adverse effects such as nausea.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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