Drug interactions
Nicardipine + Topotecan
Severity: Moderate
Nicardipine and Topotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine inhibits P-glycoprotein and may raise topotecan exposure, especially with oral dosing. Increased levels may worsen myelosuppression and gastrointestinal toxicity.
What this interaction means in plain words
Nicardipine and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Topotecan belongs to Oncology.
Why it happens
Inhibition of P-glycoprotein and possibly BCRP efflux increases topotecan absorption and reduces clearance.
What to do
Monitor blood counts closely, particularly with oral topotecan, and consider an alternative antihypertensive. Reduce topotecan dose if marked myelosuppression occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporine + Topotecan Major
- Cyclosporin + Topotecan Major
Frequently asked questions
Can I take Nicardipine with Topotecan?
MediHelp rates the interaction as moderate. Nicardipine and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine inhibits P-glycoprotein and may raise topotecan exposure, especially with oral dosing. Increased levels may worsen myelosuppression and gastrointestinal toxicity.
How serious is the interaction between Nicardipine and Topotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts closely, particularly with oral topotecan, and consider an alternative antihypertensive. Reduce topotecan dose if marked myelosuppression occurs.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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