Drug interactions
Nicardipine + Treprostinil
Severity: Moderate
Nicardipine and Treprostinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Treprostinil is a potent vasodilator, and combining it with nicardipine may cause additive blood pressure lowering. Symptomatic hypotension is possible, especially at initiation or dose increases.
What this interaction means in plain words
Nicardipine and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Treprostinil belongs to Cardiovascular.
Why it happens
Additive vasodilation through prostacyclin receptor agonism and calcium channel blockade.
What to do
Monitor blood pressure and symptoms of hypotension; reduce the nicardipine dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Treprostinil
Frequently asked questions
Can I take Nicardipine with Treprostinil?
MediHelp rates the interaction as moderate. Nicardipine and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Treprostinil is a potent vasodilator, and combining it with nicardipine may cause additive blood pressure lowering. Symptomatic hypotension is possible, especially at initiation or dose increases.
How serious is the interaction between Nicardipine and Treprostinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of hypotension; reduce the nicardipine dose if hypotension occurs.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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