Drug interactions
Nicardipine + Umeclidinium-vilanterol
Severity: Minor
Nicardipine and Umeclidinium-vilanterol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine is a weak to moderate CYP3A4 inhibitor and may slightly increase vilanterol levels. The expected clinical effect is small at inhaled doses.
What this interaction means in plain words
Nicardipine and Umeclidinium-vilanterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nicardipine belongs to Cardiovascular; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Weak CYP3A4 inhibition reducing vilanterol metabolism.
What to do
No dose change is generally required. Monitor heart rate and symptoms of excess beta-agonist effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Nicardipine
Frequently asked questions
Can I take Nicardipine with Umeclidinium-vilanterol?
MediHelp rates the interaction as minor. Nicardipine and Umeclidinium-vilanterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine is a weak to moderate CYP3A4 inhibitor and may slightly increase vilanterol levels. The expected clinical effect is small at inhaled doses.
How serious is the interaction between Nicardipine and Umeclidinium-vilanterol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required. Monitor heart rate and symptoms of excess beta-agonist effect.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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