Drug interactions
Nicardipine + Venetoclax
Severity: Moderate
Nicardipine and Venetoclax: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venetoclax is a CYP3A4 substrate, and higher exposure increases the risk of neutropenia and tumor lysis syndrome, especially during ramp-up. Nicardipine is a weaker inhibitor than the strong agents that are contraindicated, but it may still raise venetoclax levels.
What this interaction means in plain words
Nicardipine and Venetoclax can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Venetoclax belongs to Miscellaneous.
Why it happens
Nicardipine inhibition of CYP3A4 metabolism of venetoclax, and possible P-glycoprotein inhibition.
What to do
Monitor blood counts and tumor lysis laboratory parameters closely, especially during ramp-up. Reduce the venetoclax dose in line with labeling for moderate CYP3A4 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Venetoclax
- Clarithromycin + Venetoclax Contraindicated
- Itraconazole + Venetoclax Contraindicated
- Ketoconazole + Venetoclax Contraindicated
- Posaconazole + Venetoclax Contraindicated
- Venetoclax + Voriconazole Contraindicated
- Amiodarone + Venetoclax Major
Frequently asked questions
Can I take Nicardipine with Venetoclax?
MediHelp rates the interaction as moderate. Nicardipine and Venetoclax can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venetoclax is a CYP3A4 substrate, and higher exposure increases the risk of neutropenia and tumor lysis syndrome, especially during ramp-up. Nicardipine is a weaker inhibitor than the strong agents that are contraindicated, but it may still raise venetoclax levels.
How serious is the interaction between Nicardipine and Venetoclax?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and tumor lysis laboratory parameters closely, especially during ramp-up. Reduce the venetoclax dose in line with labeling for moderate CYP3A4 inhibitors.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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