Drug interactions
Nicardipine + Verapamil
Severity: Moderate
Nicardipine and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil inhibits CYP3A4 and may raise nicardipine concentrations. Combining two calcium channel blockers adds hypotensive effect, and verapamil also adds negative chronotropic and inotropic effects.
What this interaction means in plain words
Nicardipine and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Verapamil belongs to Cardiovascular.
Why it happens
CYP3A4 inhibition by verapamil plus additive calcium channel blockade.
What to do
Avoid routine combination. If used, monitor blood pressure, heart rate and ECG, and reduce the nicardipine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Nicardipine with Verapamil?
MediHelp rates the interaction as moderate. Nicardipine and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil inhibits CYP3A4 and may raise nicardipine concentrations. Combining two calcium channel blockers adds hypotensive effect, and verapamil also adds negative chronotropic and inotropic effects.
How serious is the interaction between Nicardipine and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combination. If used, monitor blood pressure, heart rate and ECG, and reduce the nicardipine dose if needed.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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