Drug interactions
Nicardipine + Zafirlukast
Severity: Moderate
Nicardipine and Zafirlukast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine is a CYP3A4 substrate, and zafirlukast may increase its levels. This can enhance vasodilation, causing hypotension, flushing, headache and peripheral edema.
What this interaction means in plain words
Nicardipine and Zafirlukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Zafirlukast belongs to Respiratory.
Why it happens
Inhibition of CYP3A4-mediated nicardipine metabolism by zafirlukast.
What to do
Monitor blood pressure and heart rate after starting zafirlukast. Lower the nicardipine dose if hypotension or edema occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Nicardipine
Frequently asked questions
Can I take Nicardipine with Zafirlukast?
MediHelp rates the interaction as moderate. Nicardipine and Zafirlukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine is a CYP3A4 substrate, and zafirlukast may increase its levels. This can enhance vasodilation, causing hypotension, flushing, headache and peripheral edema.
How serious is the interaction between Nicardipine and Zafirlukast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate after starting zafirlukast. Lower the nicardipine dose if hypotension or edema occurs.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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