Drug interactions
Nifedipine + Nisoldipine
Severity: Moderate
Nifedipine and Nisoldipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two dihydropyridine calcium channel blockers have the same pharmacologic action, so combining them adds hypotension, reflex tachycardia and edema without a clear therapeutic benefit. Nifedipine may also modestly raise nisoldipine levels, which is a CYP3A4 substrate.
What this interaction means in plain words
Nifedipine and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nifedipine belongs to Cardiovascular; Nisoldipine belongs to Cardiovascular.
Why it happens
Additive calcium channel blockade at vascular smooth muscle, with possible competition for CYP3A4 metabolism.
What to do
Avoid combining two dihydropyridines; use one agent and titrate it. If both are used, monitor blood pressure and edema.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Nifedipine with Nisoldipine?
MediHelp rates the interaction as moderate. Nifedipine and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Two dihydropyridine calcium channel blockers have the same pharmacologic action, so combining them adds hypotension, reflex tachycardia and edema without a clear therapeutic benefit. Nifedipine may also modestly raise nisoldipine levels, which is a CYP3A4 substrate.
How serious is the interaction between Nifedipine and Nisoldipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two dihydropyridines; use one agent and titrate it. If both are used, monitor blood pressure and edema.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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