Drug interactions
Nifedipine + Ribociclib
Severity: Moderate
Nifedipine and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate to strong CYP3A4 inhibitor and can raise nifedipine concentrations. This may cause hypotension, flushing, headache and peripheral edema. Ribociclib also prolongs the QT interval, but nifedipine is not a notable QT-prolonging drug.
What this interaction means in plain words
Nifedipine and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nifedipine belongs to Cardiovascular; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4-mediated metabolism of nifedipine, increasing its exposure.
What to do
Monitor blood pressure and heart rate when ribociclib is started. Reduce the nifedipine dose if hypotension or edema develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Nifedipine with Ribociclib?
MediHelp rates the interaction as moderate. Nifedipine and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a moderate to strong CYP3A4 inhibitor and can raise nifedipine concentrations. This may cause hypotension, flushing, headache and peripheral edema. Ribociclib also prolongs the QT interval, but nifedipine is not a notable QT-prolonging drug.
How serious is the interaction between Nifedipine and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when ribociclib is started. Reduce the nifedipine dose if hypotension or edema develops.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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