Drug interactions
Nifedipine + Sirolimus
Severity: Moderate
Nifedipine and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine may modestly raise sirolimus concentrations. Higher levels increase the risk of sirolimus adverse effects such as hyperlipidemia, cytopenias and impaired wound healing.
What this interaction means in plain words
Nifedipine and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nifedipine belongs to Cardiovascular; Sirolimus belongs to Miscellaneous.
Why it happens
Weak inhibition of CYP3A4 and P-glycoprotein reduces sirolimus clearance.
What to do
Monitor sirolimus trough concentrations when nifedipine is started, changed or stopped. Adjust the sirolimus dose to the target range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Nifedipine with Sirolimus?
MediHelp rates the interaction as moderate. Nifedipine and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nifedipine may modestly raise sirolimus concentrations. Higher levels increase the risk of sirolimus adverse effects such as hyperlipidemia, cytopenias and impaired wound healing.
How serious is the interaction between Nifedipine and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough concentrations when nifedipine is started, changed or stopped. Adjust the sirolimus dose to the target range.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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