Drug interactions
Nifedipine + Solifenacin
Severity: Minor
Nifedipine and Solifenacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine is a CYP3A4 substrate with at most weak inhibitory effect, so a meaningful rise in solifenacin levels is unlikely. Both drugs can contribute to constipation and, with nifedipine, reflex tachycardia.
What this interaction means in plain words
Nifedipine and Solifenacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nifedipine belongs to Cardiovascular; Solifenacin belongs to Genitourinary.
Why it happens
Possible weak CYP3A4 competition; no established clinically significant mechanism.
What to do
No dose adjustment is needed; monitor for constipation and anticholinergic effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Solifenacin
Other interactions of Nifedipine
Frequently asked questions
Can I take Nifedipine with Solifenacin?
MediHelp rates the interaction as minor. Nifedipine and Solifenacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nifedipine is a CYP3A4 substrate with at most weak inhibitory effect, so a meaningful rise in solifenacin levels is unlikely. Both drugs can contribute to constipation and, with nifedipine, reflex tachycardia.
How serious is the interaction between Nifedipine and Solifenacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for constipation and anticholinergic effects.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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