Drug interactions
Nifedipine + Tazemetostat
Severity: Moderate
Nifedipine and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak-to-moderate CYP3A inducer and may reduce exposure to sensitive CYP3A substrates such as nifedipine, weakening blood pressure control. Nifedipine is not a significant inhibitor of CYP3A4, so the reverse effect is unlikely to matter.
What this interaction means in plain words
Nifedipine and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nifedipine belongs to Cardiovascular; Tazemetostat belongs to Miscellaneous.
Why it happens
Tazemetostat induces CYP3A4, increasing nifedipine metabolism.
What to do
Monitor blood pressure and anginal symptoms, and increase the nifedipine dose if control is lost. Consider an alternative antihypertensive if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Other interactions of Tazemetostat
Frequently asked questions
Can I take Nifedipine with Tazemetostat?
MediHelp rates the interaction as moderate. Nifedipine and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is a weak-to-moderate CYP3A inducer and may reduce exposure to sensitive CYP3A substrates such as nifedipine, weakening blood pressure control. Nifedipine is not a significant inhibitor of CYP3A4, so the reverse effect is unlikely to matter.
How serious is the interaction between Nifedipine and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and anginal symptoms, and increase the nifedipine dose if control is lost. Consider an alternative antihypertensive if needed.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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