Drug interactions
Nifedipine + Tipranavir
Severity: Major
Nifedipine and Tipranavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, given with ritonavir, has net CYP3A4 inhibitory effects and can increase nifedipine exposure, with risk of hypotension, edema and tachycardia. Nifedipine is unlikely to meaningfully change tipranavir levels.
What this interaction means in plain words
Nifedipine and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nifedipine belongs to Cardiovascular; Tipranavir belongs to Anti Virals.
Why it happens
Ritonavir-boosted tipranavir inhibits CYP3A4 metabolism of nifedipine.
What to do
Start nifedipine at a low dose and titrate to blood pressure, monitoring for edema and tachycardia. Consider an alternative antihypertensive if tolerability is poor.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nifedipine
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Nifedipine with Tipranavir?
MediHelp rates the interaction as major. Nifedipine and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tipranavir, given with ritonavir, has net CYP3A4 inhibitory effects and can increase nifedipine exposure, with risk of hypotension, edema and tachycardia. Nifedipine is unlikely to meaningfully change tipranavir levels.
How serious is the interaction between Nifedipine and Tipranavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start nifedipine at a low dose and titrate to blood pressure, monitoring for edema and tachycardia. Consider an alternative antihypertensive if tolerability is poor.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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