Drug interactions
Nilotinib + Omeprazole
Severity: Moderate
Nilotinib and Omeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib capsules dissolve poorly at higher pH, and PPIs can reduce its exposure, possibly diminishing efficacy in leukemia. The effect of acid suppression is long-lasting, so dose separation may not fully avoid it.
What this interaction means in plain words
Nilotinib and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nilotinib belongs to Oncology; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Elevated gastric pH lowers nilotinib solubility and absorption.
What to do
If acid suppression is necessary, use an H2 blocker taken about 10 hours before and 2 hours after nilotinib or a short-acting antacid separated by 2 hours; monitor response and QT.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Omeprazole?
MediHelp rates the interaction as moderate. Nilotinib and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib capsules dissolve poorly at higher pH, and PPIs can reduce its exposure, possibly diminishing efficacy in leukemia. The effect of acid suppression is long-lasting, so dose separation may not fully avoid it.
How serious is the interaction between Nilotinib and Omeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If acid suppression is necessary, use an H2 blocker taken about 10 hours before and 2 hours after nilotinib or a short-acting antacid separated by 2 hours; monitor response and QT.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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