Drug interactions
Nilotinib + Osilodrostat
Severity: Major
Nilotinib and Osilodrostat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so concurrent use may cause additive prolongation. This increases the risk of ventricular arrhythmias, especially with electrolyte abnormalities.
What this interaction means in plain words
Nilotinib and Osilodrostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nilotinib belongs to Oncology; Osilodrostat belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid if possible, otherwise obtain a baseline ECG and monitor periodically. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Osilodrostat
Frequently asked questions
Can I take Nilotinib with Osilodrostat?
MediHelp rates the interaction as major. Nilotinib and Osilodrostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so concurrent use may cause additive prolongation. This increases the risk of ventricular arrhythmias, especially with electrolyte abnormalities.
How serious is the interaction between Nilotinib and Osilodrostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, otherwise obtain a baseline ECG and monitor periodically. Correct potassium and magnesium abnormalities.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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