Drug interactions
Nilotinib + Piroxicam
Severity: Minor
Nilotinib and Piroxicam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib may modestly increase piroxicam exposure, which could enhance NSAID related adverse effects. The effect is expected to be minor.
What this interaction means in plain words
Nilotinib and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nilotinib belongs to Oncology; Piroxicam belongs to Musculoskeletal.
Why it happens
Nilotinib inhibits CYP2C9 in vitro, potentially reducing piroxicam clearance.
What to do
No routine adjustment is needed. Monitor for gastrointestinal bleeding, fluid retention and renal changes with prolonged use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Piroxicam?
MediHelp rates the interaction as minor. Nilotinib and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nilotinib may modestly increase piroxicam exposure, which could enhance NSAID related adverse effects. The effect is expected to be minor.
How serious is the interaction between Nilotinib and Piroxicam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for gastrointestinal bleeding, fluid retention and renal changes with prolonged use.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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