Drug interactions
Nilotinib + Ribociclib
Severity: Major
Nilotinib and Ribociclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lengthen the QT interval and ribociclib is also a CYP3A4 substrate affected by nilotinib's inhibition. Together they can produce clinically important QT prolongation and arrhythmia.
What this interaction means in plain words
Nilotinib and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nilotinib belongs to Oncology; Ribociclib belongs to Oncology.
Why it happens
Additive QT prolongation, with possible increased ribociclib exposure from CYP3A4 inhibition by nilotinib.
What to do
Avoid concurrent use when an alternative exists. If co-administered, monitor ECG and electrolytes at baseline and regularly during therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Nilotinib with Ribociclib?
MediHelp rates the interaction as major. Nilotinib and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs lengthen the QT interval and ribociclib is also a CYP3A4 substrate affected by nilotinib's inhibition. Together they can produce clinically important QT prolongation and arrhythmia.
How serious is the interaction between Nilotinib and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use when an alternative exists. If co-administered, monitor ECG and electrolytes at baseline and regularly during therapy.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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