Drug interactions
Nilotinib + Rilpivirine
Severity: Major
Nilotinib and Rilpivirine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both nilotinib and rilpivirine can prolong the QT interval, and rilpivirine does so mainly at supratherapeutic doses. Taking them together may add to the risk of torsades de pointes, especially in patients with electrolyte disturbances or heart disease.
What this interaction means in plain words
Nilotinib and Rilpivirine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nilotinib belongs to Oncology; Rilpivirine belongs to Anti Virals.
Why it happens
Additive pharmacodynamic QT prolongation through cardiac repolarization (hERG) effects.
What to do
Obtain a baseline ECG and correct potassium and magnesium before starting, then repeat ECGs periodically during co-therapy. Consider an alternative antiretroviral if the QTc rises significantly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Nilotinib with Rilpivirine?
MediHelp rates the interaction as major. Nilotinib and Rilpivirine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both nilotinib and rilpivirine can prolong the QT interval, and rilpivirine does so mainly at supratherapeutic doses. Taking them together may add to the risk of torsades de pointes, especially in patients with electrolyte disturbances or heart disease.
How serious is the interaction between Nilotinib and Rilpivirine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before starting, then repeat ECGs periodically during co-therapy. Consider an alternative antiretroviral if the QTc rises significantly.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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