Drug interactions
Nilotinib + Rivaroxaban
Severity: Moderate
Nilotinib and Rivaroxaban: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib is a weak to moderate CYP3A4 inhibitor and also affects P-glycoprotein, so it can raise rivaroxaban exposure. The effect is likely larger in patients with renal impairment, where both elimination routes of rivaroxaban are already reduced, and this raises the bleeding risk.
What this interaction means in plain words
Nilotinib and Rivaroxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nilotinib belongs to Oncology; Rivaroxaban belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein by nilotinib reduces rivaroxaban clearance.
What to do
Monitor for bleeding signs and check hemoglobin periodically. In patients with renal impairment, use the combination only if the expected benefit outweighs the risk and consider an alternative anticoagulant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Rivaroxaban?
MediHelp rates the interaction as moderate. Nilotinib and Rivaroxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib is a weak to moderate CYP3A4 inhibitor and also affects P-glycoprotein, so it can raise rivaroxaban exposure. The effect is likely larger in patients with renal impairment, where both elimination routes of rivaroxaban are already reduced, and this raises the bleeding risk.
How serious is the interaction between Nilotinib and Rivaroxaban?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs and check hemoglobin periodically. In patients with renal impairment, use the combination only if the expected benefit outweighs the risk and consider an alternative anticoagulant.
What other medicines interact with Rivaroxaban?
MediHelp also lists interactions of Rivaroxaban with, for example, Defibrotide, Ketoconazole, Ketorolac. The full list is on the Rivaroxaban page.
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