Drug interactions
Nilotinib + Saxagliptin
Severity: Minor
Nilotinib and Saxagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib is a weak to moderate CYP3A4 inhibitor and could raise saxagliptin exposure. The effect is expected to be small, but both drugs warrant attention in patients with other risk factors.
What this interaction means in plain words
Nilotinib and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nilotinib belongs to Oncology; Saxagliptin belongs to Endocrine.
Why it happens
Nilotinib inhibits CYP3A4-mediated metabolism of saxagliptin.
What to do
No routine dose change. Monitor blood glucose and adverse effects of saxagliptin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Saxagliptin?
MediHelp rates the interaction as minor. Nilotinib and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nilotinib is a weak to moderate CYP3A4 inhibitor and could raise saxagliptin exposure. The effect is expected to be small, but both drugs warrant attention in patients with other risk factors.
How serious is the interaction between Nilotinib and Saxagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change. Monitor blood glucose and adverse effects of saxagliptin.
What other medicines interact with Saxagliptin?
MediHelp also lists interactions of Saxagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Saxagliptin page.
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