Drug interactions
Nilotinib + Solifenacin
Severity: Major
Nilotinib and Solifenacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP3A4 and can raise solifenacin exposure, and both drugs prolong the QT interval. Nilotinib carries a boxed warning for QT prolongation and sudden death, so the combination raises arrhythmia risk.
What this interaction means in plain words
Nilotinib and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nilotinib belongs to Oncology; Solifenacin belongs to Genitourinary.
Why it happens
CYP3A4 inhibition by nilotinib plus additive QT prolongation.
What to do
Avoid if possible and choose a bladder agent without QT effects such as mirabegron. If unavoidable, monitor ECG and electrolytes and use the lowest solifenacin dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Solifenacin
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Solifenacin?
MediHelp rates the interaction as major. Nilotinib and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nilotinib inhibits CYP3A4 and can raise solifenacin exposure, and both drugs prolong the QT interval. Nilotinib carries a boxed warning for QT prolongation and sudden death, so the combination raises arrhythmia risk.
How serious is the interaction between Nilotinib and Solifenacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and choose a bladder agent without QT effects such as mirabegron. If unavoidable, monitor ECG and electrolytes and use the lowest solifenacin dose.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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