Drug interactions
Nilotinib + Trastuzumab deruxtecan
Severity: Moderate
Nilotinib and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause myelosuppression including neutropenia, so combined use may increase the risk of infection. Trastuzumab deruxtecan also carries a risk of interstitial lung disease and left ventricular dysfunction.
What this interaction means in plain words
Nilotinib and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nilotinib belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive pharmacodynamic bone marrow suppression.
What to do
Monitor complete blood counts regularly and interrupt or reduce doses according to labeled neutropenia guidance. Counsel patients to report fever or infection promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Nilotinib with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Nilotinib and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause myelosuppression including neutropenia, so combined use may increase the risk of infection. Trastuzumab deruxtecan also carries a risk of interstitial lung disease and left ventricular dysfunction.
How serious is the interaction between Nilotinib and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and interrupt or reduce doses according to labeled neutropenia guidance. Counsel patients to report fever or infection promptly.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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