Drug interactions
Nisoldipine + Rocuronium
Severity: Minor
Nisoldipine and Rocuronium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers can modestly potentiate non-depolarizing neuromuscular blockers such as rocuronium. The effect is usually small but may prolong block.
What this interaction means in plain words
Nisoldipine and Rocuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nisoldipine belongs to Cardiovascular; Rocuronium belongs to Musculoskeletal.
Why it happens
Calcium channel blockade reduces prejunctional calcium-dependent acetylcholine release, enhancing neuromuscular block.
What to do
Titrate rocuronium using train-of-four monitoring and confirm full recovery before extubation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rocuronium
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Nisoldipine with Rocuronium?
MediHelp rates the interaction as minor. Nisoldipine and Rocuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium channel blockers can modestly potentiate non-depolarizing neuromuscular blockers such as rocuronium. The effect is usually small but may prolong block.
How serious is the interaction between Nisoldipine and Rocuronium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate rocuronium using train-of-four monitoring and confirm full recovery before extubation.
What other medicines interact with Rocuronium?
MediHelp also lists interactions of Rocuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Rocuronium page.
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