Drug interactions
Nisoldipine + Tadalafil
Severity: Moderate
Nisoldipine and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents lower blood pressure through vasodilation, so combined use can cause additive hypotension. Dizziness, syncope or falls may occur, especially at initiation or after dose increases.
What this interaction means in plain words
Nisoldipine and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nisoldipine belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
Why it happens
Additive vasodilation: PDE5 inhibition enhances nitric oxide-cGMP signalling while nisoldipine blocks L-type calcium channels.
What to do
Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug. Start tadalafil at the lowest dose in patients on stable antihypertensive therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Nisoldipine with Tadalafil?
MediHelp rates the interaction as moderate. Nisoldipine and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents lower blood pressure through vasodilation, so combined use can cause additive hypotension. Dizziness, syncope or falls may occur, especially at initiation or after dose increases.
How serious is the interaction between Nisoldipine and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug. Start tadalafil at the lowest dose in patients on stable antihypertensive therapy.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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