Drug interactions
Nisoldipine + Timolol
Severity: Moderate
Nisoldipine and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Timolol combined with nisoldipine can lower blood pressure more than either agent alone. Rarely, heart failure may worsen or heart rate may fall excessively in vulnerable patients.
What this interaction means in plain words
Nisoldipine and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nisoldipine belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects of beta-blockade and dihydropyridine vasodilation.
What to do
Monitor blood pressure and heart rate when starting or adjusting either agent. Titrate gradually, particularly in patients with impaired ventricular function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Nisoldipine with Timolol?
MediHelp rates the interaction as moderate. Nisoldipine and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Timolol combined with nisoldipine can lower blood pressure more than either agent alone. Rarely, heart failure may worsen or heart rate may fall excessively in vulnerable patients.
How serious is the interaction between Nisoldipine and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting either agent. Titrate gradually, particularly in patients with impaired ventricular function.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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