Drug interactions
Nitrofurantoin + Safinamide
Severity: Minor
Nitrofurantoin and Safinamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Safinamide may inhibit intestinal BCRP, which could increase the absorption of BCRP substrates. Nitrofurantoin may be a BCRP substrate, so a small rise in exposure is theoretically possible but unlikely to matter clinically.
What this interaction means in plain words
Nitrofurantoin and Safinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nitrofurantoin belongs to Anti Bacterial; Safinamide belongs to Central Nervous System.
Why it happens
Inhibition of intestinal BCRP efflux transporter by safinamide, potentially raising nitrofurantoin absorption.
What to do
No dose adjustment is needed. Be aware of increased nitrofurantoin adverse effects such as nausea or neuropathy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nitrofurantoin
Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Nitrofurantoin with Safinamide?
MediHelp rates the interaction as minor. Nitrofurantoin and Safinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Safinamide may inhibit intestinal BCRP, which could increase the absorption of BCRP substrates. Nitrofurantoin may be a BCRP substrate, so a small rise in exposure is theoretically possible but unlikely to matter clinically.
How serious is the interaction between Nitrofurantoin and Safinamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Be aware of increased nitrofurantoin adverse effects such as nausea or neuropathy.
What other medicines interact with Nitrofurantoin?
MediHelp also lists interactions of Nitrofurantoin with, for example, Pexidartinib, Pretomanid, Aluminum hydroxide. The full list is on the Nitrofurantoin page.
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