Drug interactions
Nitrofurantoin + Sofosbuvir-velpatasvir
Severity: Minor
Nitrofurantoin and Sofosbuvir-velpatasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir may increase nitrofurantoin absorption through BCRP inhibition. Nitrofurantoin acts mainly in urine, so a meaningful clinical effect is unlikely.
What this interaction means in plain words
Nitrofurantoin and Sofosbuvir-velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nitrofurantoin belongs to Anti Bacterial; Sofosbuvir-velpatasvir belongs to Anti Virals.
Why it happens
Velpatasvir inhibits intestinal BCRP, which may increase nitrofurantoin absorption.
What to do
No dose adjustment is needed. Monitor for nausea and, with prolonged use, for pulmonary or hepatic adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nitrofurantoin and Sofosbuvir-velpatasvir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Sofosbuvir-velpatasvir
- Rifampin + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Sofosbuvir-velpatasvir + St john's wort Contraindicated
- Amiodarone + Sofosbuvir-velpatasvir Major
- Apalutamide + Sofosbuvir-velpatasvir Major
- Carbamazepine + Sofosbuvir-velpatasvir Major
Other interactions of Nitrofurantoin
Frequently asked questions
Can I take Nitrofurantoin with Sofosbuvir-velpatasvir?
MediHelp rates the interaction as minor. Nitrofurantoin and Sofosbuvir-velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Velpatasvir may increase nitrofurantoin absorption through BCRP inhibition. Nitrofurantoin acts mainly in urine, so a meaningful clinical effect is unlikely.
How serious is the interaction between Nitrofurantoin and Sofosbuvir-velpatasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for nausea and, with prolonged use, for pulmonary or hepatic adverse effects.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
