Drug interactions
Nitroglycerin rectal + Sotalol
Severity: Moderate
Nitroglycerin rectal and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitroglycerin lowers blood pressure, and sotalol blunts the reflex tachycardia that would normally compensate. The combination can cause additive hypotension, though it is often used intentionally in angina.
What this interaction means in plain words
Nitroglycerin rectal and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotension from venodilation and beta-blockade, with loss of reflex tachycardia.
What to do
Monitor blood pressure and symptoms of hypotension, especially when starting treatment or increasing doses. Advise patients to change position slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nitroglycerin rectal and Sotalol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Nitroglycerin rectal with Sotalol?
MediHelp rates the interaction as moderate. Nitroglycerin rectal and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitroglycerin lowers blood pressure, and sotalol blunts the reflex tachycardia that would normally compensate. The combination can cause additive hypotension, though it is often used intentionally in angina.
How serious is the interaction between Nitroglycerin rectal and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of hypotension, especially when starting treatment or increasing doses. Advise patients to change position slowly.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
