Drug interactions
Nizatidine + Pexidartinib
Severity: Moderate
Nizatidine and Pexidartinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib solubility is pH-dependent, so acid-reducing drugs can lower its absorption and potentially reduce efficacy.
What this interaction means in plain words
Nizatidine and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nizatidine belongs to Gastrointestinal Tract; Pexidartinib belongs to Oncology.
Why it happens
Nizatidine raises gastric pH, decreasing pexidartinib dissolution and absorption.
What to do
Take pexidartinib 2 hours before or 10 hours after nizatidine, or use a locally acting antacid instead.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nizatidine
- Atazanavir + Nizatidine Major
- Dasatinib + Nizatidine Major
- Erlotinib + Nizatidine Major
- Itraconazole + Nizatidine Major
- Ketoconazole + Nizatidine Major
- Nizatidine + Pazopanib Major
Other interactions of Pexidartinib
Frequently asked questions
Can I take Nizatidine with Pexidartinib?
MediHelp rates the interaction as moderate. Nizatidine and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pexidartinib solubility is pH-dependent, so acid-reducing drugs can lower its absorption and potentially reduce efficacy.
How serious is the interaction between Nizatidine and Pexidartinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take pexidartinib 2 hours before or 10 hours after nizatidine, or use a locally acting antacid instead.
What other medicines interact with Nizatidine?
MediHelp also lists interactions of Nizatidine with, for example, Atazanavir, Dasatinib, Erlotinib. The full list is on the Nizatidine page.
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