Drug interactions
Nizatidine + Vitamin B12
Severity: Minor
Nizatidine and Vitamin B12: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histamine H2 receptor antagonists reduce gastric acid secretion, which can lessen release of food-bound vitamin B12. With prolonged use, B12 levels may fall modestly, though clinical deficiency is uncommon.
What this interaction means in plain words
Nizatidine and Vitamin B12 have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nizatidine belongs to Gastrointestinal Tract; Vitamin B12 belongs to Gastrointestinal Tract.
Why it happens
Reduced gastric acidity impairs liberation of protein-bound vitamin B12 for absorption.
What to do
Monitor B12 status in patients on prolonged acid suppression with additional risk factors or neurologic or hematologic symptoms. Supplement if deficient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vitamin B12
- Chloramphenicol + Vitamin B12 Moderate
- Dichlorphenamide + Vitamin B12 Moderate
- Metformin + Vitamin B12 Moderate
- Neomycin po + Vitamin B12 Moderate
- Aspirin / citric acid / sodium bicarbonate + Vitamin B12 Minor
- Aspirin + Vitamin B12 Minor
Other interactions of Nizatidine
- Atazanavir + Nizatidine Major
- Dasatinib + Nizatidine Major
- Erlotinib + Nizatidine Major
- Itraconazole + Nizatidine Major
- Ketoconazole + Nizatidine Major
- Nizatidine + Pazopanib Major
Frequently asked questions
Can I take Nizatidine with Vitamin B12?
MediHelp rates the interaction as minor. Nizatidine and Vitamin B12 have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Histamine H2 receptor antagonists reduce gastric acid secretion, which can lessen release of food-bound vitamin B12. With prolonged use, B12 levels may fall modestly, though clinical deficiency is uncommon.
How serious is the interaction between Nizatidine and Vitamin B12?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor B12 status in patients on prolonged acid suppression with additional risk factors or neurologic or hematologic symptoms. Supplement if deficient.
What other medicines interact with Vitamin B12?
MediHelp also lists interactions of Vitamin B12 with, for example, Chloramphenicol, Dichlorphenamide, Metformin. The full list is on the Vitamin B12 page.
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