Drug interactions
Norepinephrine + Trazodone
Severity: Moderate
Norepinephrine and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone has alpha-1 blocking and weak reuptake effects, so it may alter the pressor response to intravenous norepinephrine. The response can be unpredictable, with either a blunted or exaggerated effect on blood pressure. This matters because norepinephrine is titrated to hemodynamic targets in critically ill patients.
What this interaction means in plain words
Norepinephrine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Trazodone's alpha-adrenergic blockade and effects on adrenergic neuronal uptake may change the vascular response to norepinephrine.
What to do
Titrate norepinephrine to measured blood pressure with continuous monitoring in patients taking trazodone. Consider holding trazodone in acute critical care settings if responses are erratic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Norepinephrine with Trazodone?
MediHelp rates the interaction as moderate. Norepinephrine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone has alpha-1 blocking and weak reuptake effects, so it may alter the pressor response to intravenous norepinephrine. The response can be unpredictable, with either a blunted or exaggerated effect on blood pressure. This matters because norepinephrine is titrated to hemodynamic targets in critically ill patients.
How serious is the interaction between Norepinephrine and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate norepinephrine to measured blood pressure with continuous monitoring in patients taking trazodone. Consider holding trazodone in acute critical care settings if responses are erratic.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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