Drug interactions
Norgestrel + Ribociclib
Severity: Minor
Norgestrel and Ribociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Norgestrel is partly metabolized by CYP3A4, and ribociclib may increase its systemic exposure, with a modest risk of progestogenic adverse effects. Hormonal contraceptives are also generally unsuitable in hormone receptor-positive breast cancer.
What this interaction means in plain words
Norgestrel and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Norgestrel belongs to Endocrine; Ribociclib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated norgestrel metabolism by ribociclib.
What to do
Prefer non-hormonal contraception during ribociclib therapy; if a progestin is used, monitor for adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Norgestrel
- Amobarbital + Norgestrel Major
- Apalutamide + Norgestrel Major
- Bosentan + Norgestrel Major
- Carbamazepine + Norgestrel Major
- Efavirenz + Norgestrel Major
- Enzalutamide + Norgestrel Major
Frequently asked questions
Can I take Norgestrel with Ribociclib?
MediHelp rates the interaction as minor. Norgestrel and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Norgestrel is partly metabolized by CYP3A4, and ribociclib may increase its systemic exposure, with a modest risk of progestogenic adverse effects. Hormonal contraceptives are also generally unsuitable in hormone receptor-positive breast cancer.
How serious is the interaction between Norgestrel and Ribociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer non-hormonal contraception during ribociclib therapy; if a progestin is used, monitor for adverse effects.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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