Drug interactions
Nortriptyline + Rilpivirine
Severity: Moderate
Nortriptyline and Rilpivirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, particularly at supratherapeutic rilpivirine exposure, and nortriptyline can also cause conduction abnormalities. The combination may raise the risk of torsades de pointes in susceptible patients.
What this interaction means in plain words
Nortriptyline and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nortriptyline belongs to Central Nervous System; Rilpivirine belongs to Anti Virals.
Why it happens
Additive QT interval prolongation.
What to do
Obtain a baseline ECG and correct potassium and magnesium abnormalities. Monitor the ECG, and avoid other QT-prolonging drugs or consider alternatives in patients with additional risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Nortriptyline with Rilpivirine?
MediHelp rates the interaction as moderate. Nortriptyline and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, particularly at supratherapeutic rilpivirine exposure, and nortriptyline can also cause conduction abnormalities. The combination may raise the risk of torsades de pointes in susceptible patients.
How serious is the interaction between Nortriptyline and Rilpivirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium abnormalities. Monitor the ECG, and avoid other QT-prolonging drugs or consider alternatives in patients with additional risk factors.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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