Drug interactions
Nortriptyline + Saxagliptin
Severity: Minor
Nortriptyline and Saxagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants may influence blood glucose, which could modestly change the response to saxagliptin. Saxagliptin rarely causes hypoglycemia on its own, so the clinical effect is minimal.
What this interaction means in plain words
Nortriptyline and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nortriptyline belongs to Central Nervous System; Saxagliptin belongs to Endocrine.
Why it happens
Possible tricyclic effects on glucose handling, not firmly established.
What to do
Monitor blood glucose when nortriptyline is started or stopped and adjust antidiabetic therapy if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Frequently asked questions
Can I take Nortriptyline with Saxagliptin?
MediHelp rates the interaction as minor. Nortriptyline and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants may influence blood glucose, which could modestly change the response to saxagliptin. Saxagliptin rarely causes hypoglycemia on its own, so the clinical effect is minimal.
How serious is the interaction between Nortriptyline and Saxagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when nortriptyline is started or stopped and adjust antidiabetic therapy if control changes.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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