Drug interactions
Nortriptyline + Solifenacin
Severity: Moderate
Nortriptyline and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nortriptyline has anticholinergic activity and can prolong QT/QRS, so combination with solifenacin increases antimuscarinic burden and may add to QT risk. This can cause urinary retention, constipation, confusion and arrhythmia, especially in older adults.
What this interaction means in plain words
Nortriptyline and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nortriptyline belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
Additive antimuscarinic effects and additive cardiac conduction/QT effects.
What to do
Monitor for anticholinergic toxicity and urinary retention, and obtain an ECG in patients with cardiac disease. Consider a non-anticholinergic bladder agent if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Nortriptyline with Solifenacin?
MediHelp rates the interaction as moderate. Nortriptyline and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nortriptyline has anticholinergic activity and can prolong QT/QRS, so combination with solifenacin increases antimuscarinic burden and may add to QT risk. This can cause urinary retention, constipation, confusion and arrhythmia, especially in older adults.
How serious is the interaction between Nortriptyline and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and urinary retention, and obtain an ECG in patients with cardiac disease. Consider a non-anticholinergic bladder agent if adverse effects occur.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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