Drug interactions
Nortriptyline + Vemurafenib
Severity: Major
Nortriptyline and Vemurafenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib can prolong the QT interval in a concentration-dependent way, and nortriptyline adds to this effect. This raises the risk of ventricular arrhythmia.
What this interaction means in plain words
Nortriptyline and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nortriptyline belongs to Central Nervous System; Vemurafenib belongs to Oncology.
Why it happens
Additive QT prolongation.
What to do
Avoid if possible; otherwise obtain baseline and periodic ECGs and correct electrolyte abnormalities.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Vemurafenib
Frequently asked questions
Can I take Nortriptyline with Vemurafenib?
MediHelp rates the interaction as major. Nortriptyline and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vemurafenib can prolong the QT interval in a concentration-dependent way, and nortriptyline adds to this effect. This raises the risk of ventricular arrhythmia.
How serious is the interaction between Nortriptyline and Vemurafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise obtain baseline and periodic ECGs and correct electrolyte abnormalities.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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